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Center for BrainHealth

Memory and higher-order cognitive functions improve; neuro-stimulation fails to enhance training benefits. Researchers at Center for BrainHealth®, part of The University of Texas at Dallas, investigated the effects of combining two non-pharmacological interventions for adults with Mild Cognitive Impairment (MCI): eight semi-weekly sessions of Strategic Memory Advanced Reasoning Tactics, or SMART™, a cognitive training program shown to improve reasoning and ability to extract the bottom-line message from complex information; and Transcranial Direct Current Stimulation (tDCS) over the left frontal region, an area associated with cognitive control and memory recovery success in people with Alzheimer's disease. Twenty-two (22) participants with a diagnosis of MCI – individuals who are at risk for Alzheimer's disease – were randomized into one of two groups: tDCS + SMART, versus sham + SMART. All participants completed a baseline cognitive assessment along with resting state cerebral blood flow, followed by post-SMART training and 3-month post-training assessments. All the participants in both groups showed immediate cognitive improvements in higher-order cognitive functions of executive functions (conceptual reasoning and fluency), sustained gains in objective episodic memory and subjective memory statistfaction. The sham + SMART group showed significant immediate gains after training on two measures of executive function – inhibition and innovation, and episodic memory. Counter to expectations, these gains were blocked in the active tDCS + SMART group. Thus, the hypothesis that neuroplasticity would be enhanced by brain stimulation to elevate training effects was not supported. The results are published in Frontiers in Neuroscience-Neural Technology in April 2019. “People with Mild Cognitive Impairment are flooded with daily life information that can overwhelm a compromised brain. Fortunately, the present results suggest they can improve cognitive functions given certain trainings,” said the study’s lead author, Namrata Das, MD, MPH, who works in the lab of chief director Dr. Sandra B. Chapman. “This study adds to the compelling evidence that cognitive training provides an intervention option to benefit people with MCI, to strengthen their cognitive capacity and even their daily memory function.” This study was funded by BvB Dallas, Sammons Enterprises, Barbara Wallace and Kelly King Charitable Foundation Trust, the AWARE fund of the Dallas 522 Foundation, and the Golden Rule Family Foundation. CONTACT Stephanie Hoefken 972.883.3221 stephanie.hoefken@utdallas.eduABOUT CENTER FOR BRAINHEALTH Center for BrainHealth®, part of The University of Texas at Dallas, is a translational research institute committed to enhancing, preserving, and restoring brain health across the lifespan. Major research areas include the use of functional and structural neuroimaging techniques to better understand the neurobiology supporting cognition and emotion in health and disease. This leading-edge scientific exploration is translated quickly into practical innovations to improve how people think, work and live, empowering people of all ages to unlock their brain potential. Translational innovations build on Strategic Memory Advanced Reasoning Tactics (SMART™), a proprietary methodology developed and tested by BrainHealth researchers and other teams over three decades.

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Sandra Bond Chapman, PhD

Chief Director Dee Wyly Distinguished Professor, School of Behavioral and Brain Sciences Co-Leader, The BrainHealth Project

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