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Jeffrey S. Spence, PhD


Director of Biostatistics

Dr. Jeff Spence is the director of biostatistics at the Center for BrainHealth® at The University of Texas at Dallas and also holds an adjunct faculty appointment in the Department of Internal Medicine, Division of Epidemiology at the University of Texas Southwestern Medical Center at Dallas.

Dr. Spence collaborates with scientists and clinical researchers across several universities and continues to mentor doctoral students, postdoctoral fellows and clinical scholars from UT Dallas, Southwestern Medical Center, as well as Southern Methodist University.

Key Research and Publications

Dr. Spence’s research interest, for which he has received NIH funding, involves the development of theory and methodology applied to analyses of functional neuroimaging studies of the human brain. His work has been published in prominent peer-reviewed journals in the fields of statistics and neuroimaging, and he has been an invited speaker at several university symposia and national technical meetings.  His research has been an important factor for aiding in the identification of mechanisms of cognitive illnesses, including the multi-symptom complex known as Gulf War Syndrome, post-traumatic stress disorder, mild cognitive impairment, traumatic brain injury and addiction.

Happy woman wearing headphones working on laptop. IStockID# 1218223744.

A Novel BrainHealth Index Prototype Improved by Telehealth-delivered Training During COVID-19

This groundbreaking study establishes a holistic, personalized measure of brain fitness (the BrainHealth® Index) and training protocols with the potential to revolutionize global health.

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Efficacy of Cognitive Training When Translated From the Laboratory to the Real World

This article presents preliminary evidence on the efficacy of SMART™ training when it is administered over a condensed time frame.

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Cognitive Training and Transcranial Direct Current Stimulation in Mild Cognitive Impairment: A Randomized Pilot Trial

Researchers have found SMART™ cognitive training significantly enhances cognitive performance in adults with mild cognitive impairment.

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Distinct Brain and Behavioral Benefits from Cognitive vs. Physical Training: A Randomized Trial in Aging Adults

Cognitive and physical training improve brain functioning and cognition, but in distinct ways.

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Enhancing Executive Function and Neural Health in Bipolar Disorder through Reasoning Training

This study provides promising evidence that short-term reasoning training can enhance cognitive performance in adults with bipolar disorder.

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