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Differences Between Combined, Isolated Use of Cannabis, Nicotine on Brain Networks

Medical Express

Center for BrainHealth

Overview

Researchers at the Center for BrainHealth at The University of Texas at Dallas investigated the effects on the brain of concurrent cannabis and nicotine use, versus the use of solely cannabis and solely nicotine. The results, recently published in the journal Brain Structure and Function, show that not only were the effects in these three categories different, but also that the group using both nicotine and cannabis more closely resembled the control (nonuser) group in brain connectivity. The isolated nicotine and isolated cannabis users showed equally less connectivity in general. Previous research in rats has suggested that nicotine may be a "gateway drug" leading to cannabis and other drug use. Studies performed with rats exposed to THC—the main psychoactive compound found in marijuana—demonstrated an increased likelihood to self-administer nicotine that was not observed with rats exposed to heroin or cocaine, suggesting that there is something unique about the cannabis-nicotine interaction. "Most of the literature to date has focused on associations of isolated cannabis and nicotine use, even though concurrent cannabis and nicotine use is more prevalent in society than cannabis use alone," said the study's lead author, Dr. Francesca M. Filbey, the Bert Moore Chair in BrainHealth at UT Dallas. "Our findings confirm the limitations of existing research." Read full story on Medical Xpress.  

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Francesca Filbey in dark blue blouse with lights, portrait. Professor and Director of Cognitive Neuroscience Research of Addictive Disorders; Bert Moore Chair; Associate Provost, UT Dallas

Francesca Filbey, PhD

Bert Moore Endowed Chair and Professor, School of Behavioral and Brain Sciences Director, Neuroimaging of Reward Dynamics (NiRD) Lab

Neuroscience of Addiction

This scholarly text, by Dr. Francesca Filbey of Center for BrainHealth, explores the neuroscience of addition from all angles including biological, cognitive, and behavioral influences.