OverviewWhen one area of the brain is damaged, it is not necessarily true that the functional damage is localized. This study explores the idea that damage to areas of the brain involved with communication between networks will have a greater impact on the whole-brain network than areas with a more localized function. To collect data on the level of connectivity between brain regions, researchers utilized mathematical tools based on graph theory, which have emerged as a way of measuring large-scale network properties of the brain. The data for this study was collected from 35 patients with focal lesions as a result of stroke, traumatic brain injury, or tumors and 24 healthy participants.
Figure 1 - An example of a graph theory mapping used to represent modular organization in the brain. Hubs have more within-module connections while connectors have more between-module connections. Note that any brain region may have both connector and hub-like properties, and may have continuous values for hubness and connectorness.
Figure 3 - A modular organization mapping of the healthy control template. Within-module edges match module solo and between-module edges are black.