Bart Rypma, PhD
Dr. Bart Rypma’s research is aimed at exploring the cognitive and neurobiological mechanisms of human memory and how these are affected by aging and disease. He uses functional magnetic resonance imaging (fMRI) to observe the activity of younger and older adults as they perform cognitive tasks.
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Key Research and Publications
Dr. Rypma has published extensively on the cognitive and neurobiological mechanisms of human memory, including high-profile publications in Proceedings of the National Academy of Science, Nature Neuroscience, Cerebral Cortex and Neuroimage.
Altered Linear Coupling Between Stimulus-Evoked Blood Flow and Oxygen Metabolism in the Aging Human Brain
Human aging affects the structural integrity of neural-vascular coupling (NVC), which plays a critical role in healthy neural function by delivering oxygen and nutrients to metabolically active neurons.
A Neural-Vascular Complex of Age-Related Changes in the Human Brain: Anatomy, Physiology, and Implications for Neurocognitive Aging
Age-related changes in neural-vascular coupling can shed light on causes of cognitive decline in older adults, and reveal limitations of current scientific knowledge.
Healthy older and younger individuals demonstrate significant differences in the brain’s blood-oxygen response, as shown with functional magnetic resonance imaging (fMRI).
MRI technology permits non-invasive monitoring of brain oxygen metabolism, a measurement shown to be predictive of fatigue and cognitive dysfunction, common effects of multiple sclerosis.
Reexamination of “Release-From-Pi” Phenomena: Recall Accuracy Does Not Recover After a Semantic Switch
Word recall improves when words are semantically different or have different meanings and declines when word are similar in semantics or meaning, a phenomenon known as proactive interference.
Q&A with Seed Grant Winner, Dr. Bart Rypma
Dr. Bart Rypma was recently awarded the Major Extramural Grant Award (MEGA) for Development of Calibrated fMRI at the UT Dallas Center for BrainHealth Imaging Center. Dr. Rypma’s research is aimed at exploring the cognitive and neurobiological mechanisms of human memory and how those mechanisms are affected by aging and disease. Dr. Rypma is a professor in the School of Behavioral and Brain Sciences at The University of Texas at Dallas and The UT Southwestern Medical Center at Dallas School of Psychiatry.