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BOLD Hemodynamic Response Function Changes Significantly with Healthy Aging

Happy elderly senior couple jogging running or walking outside on a wooded trail. Older.


Kathryn L. West, Mark Zuppichini, Monroe P. Turner, Dinesh K. Sivakolundu, Yuguang Zhao, Dema Abdelkarim, Jeffrey S. Spence and Bart Rypma

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Hemodynamic response function (HRF) characterizes the blood-oxygen-level-dependent (BOLD) signal of the brain over time through functional magnetic resonance imaging (fMRI). HRF can change over time as we age, and this is an important measurement in studies of the aging brain and its function. This study sought to use a large sample size to assess the HRF changes in healthy aging participants. The HRF was calculated in the visual, auditory, and motor cortices and there was found to be a significant difference for all three between older and younger participants. These neurovascular changes due to ages are relatively new findings, and further studies will continue to explore the implications of such discovery.

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Jeffrey S. Spence, PhD

Director of Biostatistics