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Baseline Cerebral Metabolism Predicts Fatigue and Cognition in Multiple Sclerosis Patients

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Neuroimage: Clinical

K.L. West, D.K. Sivakolundu, G.B. Maruthy, G.B., M.D. Zuppichini, P. Liu, B.P. Thomas, J.S. Spence, H. Lu, D.T. Okuda and B. Rypma

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Individuals with multiple sclerosis (MS) typically experience fatigue and cognitive dysfunction, but the mechanisms of those specific symptoms are unknown. Resting cellular activity can be measured through global brain oxygen metabolism and was hypothesized here to reflect MS disease activity and predict symptoms of fatigue and cognitive dysfunction. By measuring the oxygen metabolism of the brains of both health and MS individuals, it was shown that lower oxygen metabolism was shown in the MS patients and predicted fatigue and cognitive performance! Lastly, it was shown that MS patients with high oxygen metabolism had reduced density of white matter suggesting advanced demyelination and autoimmune activity as a result of the disease. 

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Jeffrey Spence portrait, white background, vertical. Director of Biostatistics at the Center for BrainHealth.

Jeffrey S. Spence, PhD

Director of Biostatistics

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Bart Rypma, PhD

Principal Investigator Professor, Behavioral and Brain Sciences at UT Dallas Meadows Foundation Endowed Chair in Behavioral and Brain Sciences Director, UT Dallas BrainHealth Imaging Center