OverviewIn patients with multiple sclerosis, white matter in the brain is damaged, causing impaired cognitive performance. This damage reduces the speed at which blood flow in the brain can change in response to changes in neural activity. Faster change times underlie faster cognitive processing speeds in healthy individuals when compared with MS patients. This suggests that intact neural-vascular communication may play a role in cognitive performance.
Relationships between performance (as measured by RT on the DSST) and (A) peak amplitude and (B) TTP in bilateral BA 9. Lines represent the best fit to the data using least-squares linear regression. Healthy controls are in blue, and MS patients are in orange.