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Relationship of Parieto-Occipital Brain Energy Phosphate Metabolism and Cognition Using 31P MRS at 7-Tesla in Amnestic Mild Cognitive Impairment

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Frontiers in Aging Neuroscience

Namrata Das, Jimin Ren, Jeffrey S. Spence, Audette Rackley and Sandra Bond Chapman

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Mild cognitive impairment (MCI) occurs when there is a deficit in cognitive function. This form of cognitive decline has a high occurrence of progression toward Alzheimer's disease (AD). In this study, researchers identified mild cognitive impairment (MCI) as a potential area to determine the relationship between cognitive and brain energy metabolism (BEM) with the goal of exploring early biomarkers of neuronal function before AD diagnosis. Using P MRS techniques, researchers observed that cognitive performance of executive function in the parieto-occipital lobe indicated an inverse relationship between BEM indices and cognitive support. Individuals with higher BEM in the parieto-occipital lobes had lower cognitive performance. These findings suggest the potential for BEM utilization as a cognitive measure of MCI. 
Figure 1. Spectral display of high-energy phosphate and membrane phospholipid phosphorus metabolites from the parieto-occipital lobe of amnestic mild cognitive impairment individual. PE, phosphoethanolamine; PC, phosphocholine; Piex and Piin inorganic phosphate external and internal, respectively; GPE, glycerophosphoethanolamine; GPC, glycerophosphocholine; PCr, phosphocreatine; ATP forms: α, β, and δ adenosine triphosphate; NAD, nicotinamide adenine dinucleotide; UDPG, uridine diphosphate glucose.

Figure 1. "Relationship of Parieto-Occipital Brain Energy Phosphate Metabolism and Cognition Using 31P MRS at 7-Tesla in Amnestic Mild Cognitive Impairment"

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Jeffrey S. Spence, PhD

Director of Biostatistics

Audette Rackley, MS, CCC-SLP

Assistant Director, Strength-Based Programs Research Clinician

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