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SMART Accelerates Rate of Cognitive Gains in Service Members With mTBI and PTSD

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Frontiers in Human Neuroscience

Erin Venza, Jeffery S. Spence, Jennifer Zientz, Cole Devlin, Jason Bailie, Andrew Darr, Ida Babakhanyan and Sandra Bond Chapman

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OVERVIEW

Cognitive strength, resilience, agility and focus have become even more essential to military readiness in today's ever-changing global climate, drawing attention to mild traumatic brain injury (mTBI) as a significant health concern for active-duty service members (ADSMs).In collaboration with the Veterans Brain Injury Center (DVBIC) Naval Hospital in Camp Pendleton, California, this randomized clinical trial examines the effectiveness of two cognitive rehabilitation (CR) protocols: Strategic Memory Advanced Reasoning Tactics (SMART™) and Study of Cognitive Rehabilitation Effectiveness (SCORE).
  • SMART: Developed and tested by BrainHealth researchers and other teams over three decades, SMART is Center for BrainHealth's proprietary methodology, teaching science-backed techniques that prime the brain, calibrate mental energy, reinforce strategic thinking and ignite innovation.
  • SCORE: An independent research-based cognitive intervention, SCORE combines compensatory strategy training with computer-based Attention Processing Training (APT-3) to support cognitive recovery and improve functional outcomes.
Mild traumatic brain injury (mTBI) is a significant health concern for ADSMs. This study compares the separate protocols, measuring improvement in higher-order cognitive functions among 148 ADSMs with mTBI and persistent cognitive complaints. While both groups showed significant improvements in complex memory and strategic learning, those participating in SMART achieved these outcomes in one-third of the training time. With participants reporting varying levels of post-traumatic stress disorder (PTSD) symptoms, this study also explores the relationship between PTSD symptom severity and cognitive outcomes. Previous research has reported an inverse relationship between PTSD and cognitive performance, including processing speed, verbal fluency and memory recall. This effect extends to critical cognitive skills such as strategic learning, information processing and adaptive thinking fluidity — abilities essential for warfighters. Findings from this study suggest the need for further research into whether a hybrid approach in this population would yield comparable results to in-person studies. Results evidence the potential of CRs as a significant treatment option to enhance the cognitive performance of ADSMs with mTBI, emphasizing the interconnectedness of psychological health and cognitive health in this population. By equipping service members with the tools to recover higher-order cognitive abilities efficiently, interventions like SMART can significantly contribute to mission readiness, ensuring warfighters are prepared to meet the complex demands of their duties. In contrast to traditional cognitive training and research in this area, which focus on bottom-up CR approaches, SMART teaches a top-down CR approach through techniques that prime the brain, calibrate mental energy, reinforce strategic thinking and ignite innovation. This study reinforces conclusions from prior research, showing that a top-down CR approach may provide a more effective pathway for improving executive function and problem-solving. The figure below demonstrates mean cognitive change (± SE) for SCORE and SMART from pre-training (1) to post-training (2) and 6-week follow-up (3). Group × Time interactions: SMART group improved more than the SCORE group from T1→T2 on *TOSL Synthesis and TOSL High-level interpretations. Main effects of time: TOSL Complex Memory and VSL Trials 2 & 3 rise significantly from T1→T2 and T1→T3 for both groups.
*The Test of Strategic Learning (TOSL), developed at Center for BrainHealth at The University of Texas at Dallas, was designed to evaluate complex information-processing abilities that are essential to effective and agile synthesis of incoming information. Participants read an approximate 600-word text and then perform three tasks: (1) summarize the text to capture the high-level ideas conveyed (abstraction and synthesis), (2) generate multiple interpretations or “take-home messages” (fluency of higher-order interpretations), and (3) recall key details from the text (complex memory). The TOSL’s structure allows researchers to examine two levels of information processing, i.e., both abstracted gist-level and complex memory performance. The TOSL has a manualized scoring system that tallies abstracted ideas, high-level synthesis and interpretations and accurate key points of detail-level responses. Alternate versions of TOSL were administered at each timepoint to minimize practice effects.
Figure 2. The figure demonstrates mean cognitive change (± SE) for SCORE and SMART from pre-training (1) to post-training (2) and 6-week follow-up (3). Group × Time interactions: SMART group improved more than the SCORE group from T1→T2 on TOSL Synthesis and TOSL High-level interpretations. Main effects of time: TOSL Complex Memory and VSL Trials 2 & 3 rise significantly from T1→T2 and T1→T3 for both groups.

Figure 2. The figure demonstrates mean cognitive change (± SE) for SCORE and SMART from pre-training (1) to post-training (2) and 6-week follow-up (3). Group × Time interactions: SMART group improved more than the SCORE group from T1→T2 on TOSL Synthesis and *TOSL High-level interpretations. Main effects of time: TOSL Complex Memory and VSL Trials 2 & 3 rise significantly from T1→T2 and T1→T3 for both groups.

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Erin Venza, MS, CCC-SLP

Head of Clinical Operations

Jeffrey S. Spence, PhD

Director of Biostatistics

Jennifer Zientz, MS, CCC-SLP

Director of Programs, Head of Clinical Services

Sandra Bond Chapman, PhD

Chief Director Dee Wyly Distinguished Professor, School of Behavioral and Brain Sciences Co-Leader, The BrainHealth Project


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