Altered Linear Coupling Between Stimulus-Evoked Blood Flow and Oxygen Metabolism in the Aging Human Brain
Monroe P. Turner, Yuguang Zhao, Dema Abdelkarim, Peiying Liu, Jeffrey S. Spence, Joanna L. Hutchison, Dinesh K. Sivakolundu, Binu P. Thomas, Nicholas A. Hubbard, Cuimei Xu, Kamil Taneja, Hanzhang Lu and Bart Rypma
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Jeffrey S. Spence, PhD
Director of Biostatistics
Bart Rypma, PhD
Principal Investigator Professor, Behavioral and Brain Sciences at UT Dallas Meadows Foundation Endowed Chair in Behavioral and Brain Sciences Director, Sammons BrainHealth Imaging Center
Preserving brain health is integral to longevity, especially in an ever-growing aging population.
A Neural-Vascular Complex of Age-Related Changes in the Human Brain: Anatomy, Physiology, and Implications for Neurocognitive Aging
Age-related changes in neural-vascular coupling can shed light on causes of cognitive decline in older adults, and reveal limitations of current scientific knowledge.
Healthy older and younger individuals demonstrate significant differences in the brain’s blood-oxygen response, as shown with functional magnetic resonance imaging (fMRI).