Facebook pixel
Go to home page

Altered Linear Coupling Between Stimulus-Evoked Blood Flow and Oxygen Metabolism in the Aging Human Brain

Grandparents with Grandchildren standing by the shore

Cerebral Cortex

Monroe P. Turner, Yuguang Zhao, Dema Abdelkarim, Peiying Liu, Jeffrey S. Spence, Joanna L. Hutchison, Dinesh K. Sivakolundu, Binu P. Thomas, Nicholas A. Hubbard, Cuimei Xu, Kamil Taneja, Hanzhang Lu and Bart Rypma

Read full research articleNeural-vascular coupling (NVC) plays a critical role in healthy neural function by delivering oxygen and nutrients to metabolically active neurons. This research team tested the hypothesis that human aging detrimentally affects the structural integrity of NVC. In both older and younger participants, researchers used calibrated functional magnetic resonance imaging (cfMRI) to measure age-related changes in cerebral blood flow (CBF) and oxygen metabolism during systematic stimulation of the visual cortex. Confirming this hypothesis, findings indicate notable differences correlated to age, with NVC measurements increasing relative to visual stimulation in younger adults, but not in older adults. Known age-related changes could not fully explain this disruption. Outcomes from this study suggest age-related, demand-dependent failures of underlying structures resulting in the comprise of the NVC system.

Share this article

Jeffrey S. Spence, PhD

Director of Biostatistics

Bart Rypma, PhD

Principal Investigator Professor, Behavioral and Brain Sciences at UT Dallas Meadows Foundation Endowed Chair in Behavioral and Brain Sciences Director, Sammons BrainHealth Imaging Center


Aging and Brain Health and How to Preserve It: What Experts Know So Far

Preserving brain health is integral to longevity, especially in an ever-growing aging population.

A Neural-Vascular Complex of Age-Related Changes in the Human Brain: Anatomy, Physiology, and Implications for Neurocognitive Aging

Age-related changes in neural-vascular coupling can shed light on causes of cognitive decline in older adults, and reveal limitations of current scientific knowledge.

Alzheimer’s Discovery Program

Receiving a diagnosis of Alzheimer’s or another form of dementia can be overwhelming. Reframe the diagnosis as an opportunity to form an action-oriented plan for the future. Take a strength-based approach that enriches the lives of families adjusting to a diagnosis of Alzheimer’s.

BOLD Hemodynamic Response Function Changes Significantly with Healthy Aging

Healthy older and younger individuals demonstrate significant differences in the brain’s blood-oxygen response, as shown with functional magnetic resonance imaging (fMRI).